nCoV_info

So far, the nCoV-2019 has been reported to share 96% sequence identity to the RaTG13
genome (EPI_ISL_402131). However, the S1 Receptor Binding Domain (RBD) of the nCoV-2019
genome was noticeably divergent between the two at amino acid residues 350 to 550 – Figure 1A.
We aimed to identity coronaviruses related to nCoV-2019 in viral metagenomics datasets available
in the public domain. In a recently published dataset describing viral diversity in
Malayan pangolins (PRJNA573298 10) we used VirMAP 11 to reconstruct a coronavirus genome
(approximately 84% complete from samples SRR10168377 2 and SRR10168378 1) that
shared 97% amino acid identity across the same RBD segment – Figure 1B. This result
indicates a potential recombination event for nCoV-2019.

pangolin=Schuppentier , https://en.wikipedia.org/wiki/Pangolin