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Messages - gsgs

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151
nCoV - discussion / Re: Tracking coronavirus: Map, data and timeline
« on: February 19, 2020, 08:19:57 am »
the format should work, but I'm not plotting these outside China,
the numbers are too low.
JoDi  has the charts :
https://docs.google.com/spreadsheets/d/1Z7VQ5xlf3BaTx_LBBblsW4hLoGYWnZyog3jqsS9Dbgc/edit#gid=1713765001


152
expert opinions / Feb.2020b
« on: February 17, 2020, 07:58:39 am »
-----------------------------------------------
Lipsitch , Feb14 :
>  but over the last few days, it appears that the rate of increase in new cases in China has slowed
> relative to the exponential growth we saw before
>  ...Unfortunately, I think it’s more likely to be that it’s gathering steam
> ...There’s likely to be a period of widespread transmission in the U.S.,
----------------------------------------------------
[THREAD]
Harvard-Uni-Direktor erklärt wissenschaftlich, warum #Coronavirus #CONVID9 wahrscheinlich
eine weltweite Pandemie wird & dabei 40-70% der Erdbevölkerung infiziert?

(Mindestens 3 weltweit anerkannte Experten haben dies bisher ebenfalls geäußert: https://bloomberg.com/news/articles/2020-02-13/coronavirus-could-infect-two-thirds-of-globe-researcher-says)

https://www.bloomberg.com/news/articles/2020-02-13/coronavirus-could-infect-two-thirds-of-globe-researcher-says


Coronavirus Could Infect Two-Thirds of Globe, Research Shows
By John Lauerman
February 13, 2020, 4:28 PM GMT+1
Updated on February 13, 2020, 6:23 PM GMT+1


 > As the number of coronavirus cases jumps dramatically in China, a top infectious-disease
 > scientist warns that things could get far worse: Two-thirds of the world’s population could catch it.
 > So says Ira Longini, an adviser to the World Health Organization who tracked studies
 > of the virus’s transmissibility in China. His estimate implies that there could eventually
 > be billions more infections than the current official tally of about 60,000.

-------------------------------------------------

Feb 14 , mlipsitch twitter
Why do I think a pandemic is likely? The infection is in many parts of China and many
countries in the world, with meaningful numbers of secondary transmissions.
The scale is much larger than SARS for example (where the US had many introductions
and no known onward transmission)
Why do I think 40-70% infected? Simple math models with oversimple assumptions would
predict far more than that given the R0 estimates in the 2-3 range (80-90%).
Making more realistic assumptions about mixing, perhaps a little help from seasonality,
brings the numbers down
pandemic flu in 1968 was estimated to _symptomatically_ infect 40% of the population,
and in 1918 30%. Those likely had R0 less than COVID-19.  Below is from https://stacks.cdc.gov/view/cdc/11425
What could make this scenario not happen? 1) conditions in Wuhan could be so
different in some fundamental way from elsewhere that we are mistaken in expecting
further outbreaks to have basic aspects in common. No reason I know of to think that
but a formal possibility
-----------------------------------------------------
Feb.24, Lipsitch
In my opinionSeems weird that @WHO Spox says some countries have stopped xmission.

Feb.23, Rivers
There will be lots of discussion about whether containment was ever possible,
and whether the measures taken to try were justified
-------------------------
And although it is seeming increasingly unlikely that we will stop transmission
entirely like we were able to with SARS and 2014 Ebola, we can and should
continue to prioritize slowing transmission down.
----------------------------
Kai Kupferschmidt  @kakape ; Branswell agrees
From the start, @WHO  has been very clear about its strategy: Fight #SARSCoV2 hard
at its source in China and keep it from establishing a foothold elsewhere.
It was always a long shot, but it was the right thing to do and it has bought the world time.
--------------------------------
 @WHO and @drtedros  have emphasized again and again that there is a “window of opportunity”
to contain #COVID19. On Friday, Tedros said he believed that window of opportunity was
still there, but narrowing. Personally, I think the last days have shown that time is up.
------------------------------------
cruiseship,prison,hospital,Iran,SKorea,Singapore
The massive efforts in China have bought us time.
-------------------------------------
The massive efforts in China have bought us time.
24.02.2020 · The World Health Organization on Monday said the new coronavirus epidemic had "peaked" in China
 The Economy by Paul Hodges, which suggests that China’s month-long lockdown makes a global debt crisis almost certain. Editor’s note:

. China’s economy cannot stand being on hold for much longer.





153
actual epidemic charts / Re: case numbers
« on: February 16, 2020, 07:16:54 pm »
I'd say 4 days. In the very first phase in late Jan. they listed cases which they were trying to cover up
until ~Jan.20

154
expert opinions / WHO
« on: February 15, 2020, 07:08:04 pm »
https://www.who.int/dg/speeches/detail/munich-security-conference
Munich Security Conference , WHO Director General , 15 February 2020

 > ... It was no coincidence that the 1918 flu pandemic erupted in the middle of the First World War,

contrary to what most scientists say, afaik

>...the emergence of a pathogen with pandemic potential, moving rapidly from country
> to country and requiring an immediate and large-scale response in countries.
> [that's] what we are seeing now
> [but clarifies that this is currently mainly in China]

 > Let me be clear: it is impossible to predict which direction this epidemic will take.

lots of people did and others are doing this impossible thing.
If the WHO gives no prediction then we must rely on others.

 > We are encouraged that the steps China has taken to contain the outbreak at its source
 > appear to have bought the world time, even though those steps have come at greater
 > cost to China itself. But it’s slowing the spread to the rest of the world.

well, China at first China benefits itself most. They contain it in Wuhan, the rest of China
is almost as free as the rest of the world. With some costly measures, though.

 > We’re encouraged that outside China, we have not yet seen widespread community transmission.

 > We’re concerned by the continued increase in the number of cases in China

cases are going down. It couldn't be better.

 >  we’re fighting an infodemic.
 > ...  Facebook, Google, Pinterest, Tencent, Twitter, TikTok, YouTube

;-)

 > [praising China]





155
nCoV - discussion / Re: estimating the cfr
« on: February 15, 2020, 04:55:53 am »

can it be worse here than in Wuhan ?
And with your estimate Wuhan has a very low CFR.
They have the 3 weeks death-delay since shutdown now.
And why is the pandemic inevitable, when China apparently succeeded to control it
despite all these initial cases without knowledge what helps ?
Are we so much worse than China ? Then quickly change the laws for
quarantine and such, import Chinese doctors and nurses,.

156
nCoV - discussion / Re: estimating the cfr
« on: February 14, 2020, 08:11:25 am »

Wuhan city had about 42,000 people infected by Jan 29, 2020,
[official number : 2251]
https://crofsblogs.typepad.com/files/2020.02.10.20021774v1.full.pdf
 the number of infected persons in other provinces fell within the range of 9-15,000,
[meant presumably 9000-15000 on Feb.09]
[official number = 6351]
most conservative estimate of 21,000 infections in the cities in
Hubei province except Wuhan, [on Feb.09]
[official number : 12729]

so the official numbers were underestimating his conservative estimates
by a factor of
19 (Wuhan,Jan29)
1.6 ( Hubei ex Wuhan , Feb09 )
1.4 ( China ex Hubei, Feb09 )

157
actual epidemic charts / Re: hubei vs. rest of China
« on: February 14, 2020, 06:42:05 am »
ahh, sorry. I'm so used to edit, that apparently I
accidentally edited your message instead of replying

-------------------------------------------------------------------------

money is always a problem , but you said "cheap"

It could be worth it in some countries.

The problem is people are infective before having symptoms and maybe
also before symptoms can be detected.

I think it must be made illegal to infect others carelessly or to not report
a risk-level and isolate/protect if required.
See China.
« Last Edit: Today at 01:01:40 am by gsgs »

158
news / Hubei press conferences
« on: February 13, 2020, 10:38:31 am »
Nr. 1-22 in one file  (2 and 19 are missing)

http://magictour.free.fr/hubei-p.txt


159
vaccine / Re: takes over a year (Jan.2020)
« on: February 13, 2020, 03:35:18 am »
----------------------------------------------------------------------
Researchers in China and the US are developing a vaccine for the new Coronavirus.
If all goes well, they may run the first tests in three months. A vaccine would be
available mid-year — at the very earliest.
https://www.dw.com/en/coronavirus-vaccine-a-race-against-time/a-52174737
------------------------------------------------------------------
Even if it all goes well, the earliest a vaccine against nCoV could be introduced would
be the summer of 2020.
-----------------------------------------------------------------
Another potential approach against the coronavirus nCoV is with monoclonal antibodies,
which can activate specific immunological reactions in the body.
Herbert Virgin at Vir Biotechnology in Illinois, USA, says his company has developed
antibodies which have shown themselves to be effective against SARS and MERS in
laboratory tests. Some were reportedly able to neutralize coronaviruses. "It's possible that
they could also treat the Wuhan virus," says Virgin.
-----------------------------------------------------------------
Prof. Mark Harris, a virologist at the School for Molecular and Cell Biology at the
University of Leeds in the UK, estimates the mortality rate of nCoV to be at 0.1 percent.
---------------------------------------------------------
A spokesman for the Institutes (NIH) said that it could be a few months before the first
 clinical trials of the vaccine get underway – and a year or more before it’s available.
----------------------------------------
Meanwhile, Baylor College of Medicine in Houston is also reported to be working on a vaccine.
----------------------------------------
so they are going to test it on animals who so far have not been found to catch the virus
 so whats that going to prove apart from if it does not kill an animal it MAY be ok for
 humans why not just test it on a confirmed subject and bypass animal crue..
--------------------------------------
Feb.12
The first vaccine targeting the new coronavirus could be 18 months away, and the outbreak
could end up creating a global threat potentially worse than terrorism, the WHO has warned.
--------------------------------------------------
At least a dozen research teams globally have already made headway in vaccine research
against the new coronavirus.
-----------------------------------------------------
Dr. Anthony Fauci, director of the NIAID, said they are on track to test their vaccine by April.
“Whenever you’re dealing with a vaccine, there’s always a potential for glitches,”
 “Right now, all those glitches, they’ve been overcome.”
Phase one of human testing will still take at least three months to complete, he said.
Then a decision has to be made about whether the vaccine will advance to a phase two trial.
“The risk is the companies now have to invest a lot of money,” Fauci said. “You would
have to do a trial of several hundred to several thousand people to see if it works —
that usually takes anywhere from several months to a couple of years.”
Even with expedited approval, phase two of the new coronavirus vaccine would require
a time investment of at least a year, he said.
------------------------------------------------
The 'holy grail' universal vaccine
Another competitive advantage the team enjoys is Hogue’s prior experience working
on a SARS vaccine, which should speed up their work on the new coronavirus vaccine,
since the new virus is about 80% similar to SARS at the genetic level.
In hindsight, Hogue wishes she had continued to work on her SARS vaccine.
"At the time we were pursuing this, we didn't have all that background and understanding
that there were a lot of these SARS-like viruses that could infect humans,” she said.
-------------------------------------------------------
An expert in infectious diseases on Monday said it was possible there could be a vaccine
against the new virus originating in China "at the very earliest" by September.
Chair of Infectious Disease Epidemiology at Imperial College London, Professor Azra Ghani,
added "it's more likely to be towards the end of the year".
----------------------------------------------------------
In Kooperation mit dem Forscherteam um Sutter arbeitet auch eine Gruppe
um den Virologen Stephan Becker, Direktor des Instituts für Virologie an der
Philipps Universität Marburg und Koordinator des Forschungsbereichs
Neu auftretende Infektionskrankheiten am Deutschen Zentrum für
Infektionsforschung (DZIF), an einem Impfstoffkandidaten.
Wenn der politische oder medizinische Druck hoch genug sei, dann würden
die Zulassungsverfahren beschleunigt, zeigten seine Erfahrungen.
-------------------------------------------------------



160
actual epidemic charts / case numbers
« on: February 12, 2020, 04:15:32 am »
some daily time series, which I think are important
to decide whether they can contain it
Time series which can be easily updated in this very first post in the thread
Jan.25-Feb.25

=======================
Feb.10-Feb.14, daily new cases, old method only
Hubei_old,2097,1638,1508,1728,1282,955
Wuhan_old,1552,1104,1072,1330,1001,?
H-W_old , 545,534, 436, 398, 281,?
hospitalised in Hubei on that day , Feb10-Feb14
25087,26121,33693,36719,38107-including 8309 with the new diagnosis

the data is no longer given since Feb.15
==============================
because to the classification changes in Hubei I add "confirmed+
2 type of suspected" (both translated to suspected by google)
since Feb14

-----------------------------------------------
Hubei ex Wuhan , daily new conformed+suspected+suspected Feb14-Feb29:
4475,4015,3669,3050,2208,1647,1886
1326,1247,1075,889,720,648,543
431,272
------------------------------------------------------
Wuhan , daily new conformed+suspected+suspected Feb14-Feb29:
4695,4107,3999,3739,3543,3038,4118
4655,3377,2543,2275,2059,2183,2096
1322,1008

---------------------------------------
Hubei ex Wuhan, daily new reported confirmed cases Jan25-Feb28:
277,291,399,525,678,842,771,
1027,1070,1103,1189,1221,946,856*,
768,697,545,534,436*=1404,913,497,
295,243,207,33,-266,312,52
89,50,35,31,26,5,3

*: change of definition

-----------------------------------------
China ex Hubei , daily new confirmed cases Jan.25-:
365,398,480,619,705,761,752,
678,722,890,728,707,696,558,
509,444,381,377,312,267,221
166,115,79,56,45,258,31
18,11,9,5

-----------------------------------------------------
China ex Hubei, daily new suspected cases Jan.25-
* since Feb.12  Hubei ex Wuhan
----,----,----,----,----,----,----,
1956,1913,1890,2014,2098,2211,2141,
1849,1736,1722,1657,757*,681,709
645,571,448,362,397,300,198
177,132,91,69

-----------------------------------------
beeing treated in hospital, Hubei, Jan.25-
----,----,2567,3349,4334,5486,6738,
8565,9618,10990,12627,14314,15804,19835,
20993,22160,25087,26121,33693*,36719,38107,
39447,40814,41937,43471,43745,42056,41036
40127,39073,37896,36242

---------------------------------------------
severe cases in hospital on that day , Hubei, Jan.25-
----,----,690,899,988,1094,1294,
1562,1701,2143,2520,3084,4002,5195,
5247,5505,6344,7241,7084*,9638,10152,
10396,9797,10970,11246,11178,10997,10892
10428,9430,8675,8326

--------------------------------------
under observation, Hubei, Jan.25-
6904,9103,15559,20336,26632,32340,36838,
43121,56088,58544,66764,64127,64057,67802,
70438,73127,76207,77195,77308*,77685,77323,
74261,71613,69270,68345,65525,63126,62787
61181,58575,53474,49438

here the charts for 5 time-series: (Jan.25-Feb.22)



by province and Hubei-cities:
https://ncovinfo.createaforum.com/actual-epidemic-charts/hubei-vs-rest-of-china/

161
nCoV - discussion / Re: estimating the cfr
« on: February 12, 2020, 12:44:56 am »
no measures were really successfull in the past to stop pandemics
or even to isolate cities, countries,continents - keeping the virus out.
Even in times without air-travel, railroad.
And all the papers, the modelings said that it can't be stopped,
just delayed,mitigated to some degree.

So I was surprised when the Chinese numbers went down.
And I'm not sure, that it were the measures. There should be differences
from city to city but apparantly in no city, in no country except maybe Wuhan it did take off yet.

-----------------------------------------------------
https://flutrackers.com/forum/forum/internet-communication/avian-flu-diary/828940-covid-19-dealing-with-imperfect-numbers

162
nCoV - discussion / Re: Scenarios for the coming months
« on: February 11, 2020, 08:05:49 am »
yes, but I think this is different.
No recombination in sight and coronavirus does proofreading
--> low mutation rate.
SARS, MERS did also not become milder.

163
nCoV - discussion / Re: estimating the cfr
« on: February 11, 2020, 08:01:11 am »
the numbers of new confirmed cases Hubei ex Wuhan and China ex Hubei
do really go down.
They did change the definition of confirmed cases somehow and hospitalizations
are still up , but -same argument- the trend should still show up,
if they underreport or change the definition abruptly.
-----------------------------
as for the CFR, I verified the 3 weeks lag , I was reading this :
https://republicanfreedom.com/2020/02/10/the-death-rate-is-up-to-5-the-harrowing-admission-of-a-wuhan-doctor/

found this while searching the link :
https://www.worldometers.info/coronavirus/coronavirus-death-rate/
 > Days from first symptom to death: 14 days

164
nCoV - discussion / Re: estimating the cfr
« on: February 11, 2020, 01:26:27 am »
you could compare the Wuhan deathrate with the deathrate outside Wuhan
to get ~ 2-3  times  more real cases in Wuhan

assuming no covered up deaths in Wuhan, assuming same real deathrates in and out Wuhan

~20 daily deaths in Wuhan, when it was quarantined. That's about the amount
in Hubei ex Wuhan now - 14 days later

so with that speed there had been ~400 cases in Wuhan ~Jan.10
redouble every 3-4 days to get 6400 cases on Jan24 , 100000 now

===========================


165
studies,summaries / Re: spread modeling
« on: February 11, 2020, 12:44:54 am »
obviously it has changed

---------------------------------------

7.2 days here:
https://github.com/blab/ncov-phylodynamics

 > We estimate an exponential doubling time of 7.2 (95% CI 5.0-12.9) days. We arrive at a median
 > estimate of the total cumulative number of worldwide infections as of Feb 8, 2020, of 55,800
 > with a 95% uncertainty interval of 17,500 to 194,400. Importantly, this approach uses genome
 > data from local and international cases and does not rely on case reporting within China.

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