Author Topic: B.1.1.7 = vui-202012/1  (Read 132 times)


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B.1.1.7 = vui-202012/1
« on: December 17, 2020, 10:48:12 pm »

twitter-thread from @Chjulian , translated from Spanish :

 Update: Headlines announce the identification of a "new variant" of the coronavirus in the UK.
 It is not clear if the new variant is responsible for the increase in cases.
However, this variant is interesting. And here I tell you why 37 / n

First, we need to understand that our immune system uses specialized mechanisms
to recognize and eliminate the virus, preventing its spread and ending disease.
The infectious period is the time in which we can transmit SARS-CoV-2 to another person

In the case of COVID19, the infectious period begins a couple of days before symptoms
develop and can last up to a couple of weeks (more details here
). The disease is generally acute, short-lived bone 39 / n

An Immunocompetent individual has a normal
immune response. When our immune
system is weakened, we say it is immunosuppressed. Immunosuppressed individuals
may have persistent infections that last for longer periods of time (months!) 40 / n

Under these conditions, SARS-CoV-2 can accumulate many more mutations than we
would expect (in a single individual) and which could be transmitted if the transmission
is successful after a long time 41 / n

Remember that it is normal for viruses to mutate and SARS-CoV-2 accumulates
(on average) one or two mutations per month at the population level 42 / n
[##  1.43 per month , ua5m1.gif {gsgs} ]

The new variant (named B.1.1.7) has 17 mutations (woah!). And it is speculated that
it could have originated in an individual with a persistent infection (for example,
an immunosuppressed individual, but we have no information about it) 43 / n

It is important to mention that our immune system goes to the battlefield as quickly
 as possible to avoid an arms race at the molecular level, reducing the chances that
the virus will produce a mutation that allows it to evade our immune response 44 / n

If the hypothesis turns out to be true, it can have important consequences for treatment.
 A persistent infection accumulates diversity and depending on how we treat it, we may
or may not cause an arms race at the molecular level 45 / n

That is, to select mutations with unknown epidemiological potential. There is no need
 to be alarmed, I just want to show how we scientists must think and articulate our strategy
to face the battle in the short, medium and long term 46 / N

Nor can we say that a persistent infection in an immunosuppressed individual is a
greater problem than infections in immunocompetent individuals. Definitely the
evolutionary forces that "moderate" the evolution of the virus are different and ... 47 / n

... we hope that the origin of B.1.1.7 was somewhat unusual and had nothing to do
 with the increase in cases (studies continue). There is also a second hypothesis
(with less support) to explain why this variant has so many 48 / n mutations

Are you sure they remember minks? there is always the slim chance that SARS-CoV-2
will adapt to other mammals (By the way, there are no minks on farms in the UK),
but a prolonged epidemic ... 49 / n

... in the fauna around us it could result in new genetic variants that could (after a while)
jump to humans with various mutations. For this and other reasons, it is important to
evaluate what is happening at the level of the fauna around us 50 / n

t really amazes me how much we learn and the twists and turns a sprout can take! 51 / n

Fortunately, there is no evidence (to date) that this variant has an impact on the severity
of the disease or on the effectiveness of 52 / n vaccines.

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Re: B.1.1.7 = vui-202012/1
« Reply #1 on: December 19, 2020, 04:41:18 am »
Boris Johnson calls crisis meeting over new Covid strain on Friday night  (Dec18)

rumors say it is 50% more transmissable

and now we also have a report from South Africa about a more transmissable strain,
also containing N501Y