vaccine > vaccine

takes over a year (Jan.2020)

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gsgs:
January 27th, 2020, 11:50 AM
Fauci,NIH : 1 year
Fauci said it would take a few months until the first phase of clinical trials begins and
more than a year until a vaccine is available

Tregoning, Imperial College at Bloomberg : 5-6 Months

University of Queensland : 16 weeks , 6 months
The team hopes to develop a vaccine over the next six months, which may be used to help
contain this outbreak,” he said. “The vaccine would be distributed to first responders,
helping to contain the virus from spreading around the world.” (Paul Young)

Dr. Tal Zaks, Moderna’s chief medical officer, committed to getting that done
on CEPI’s 16-week timeline. And the company will be able to manufacture the
eventual vaccine in a matter of a few months, Zaks said. That should cover
clinical trials, he said, but if the vaccine ends up working — and the 2019-nCoV
outbreak drags on — the company would have to rely on someone else to
churn out the massive number of doses required to halt the virus.

David Weiner , Inovio : "much faster".

Gregory Glenn from Novavax says that his firm is working on developing a
vaccine for the China coronavirus, and work on that could take two to three months.

CEPI : In 16 Wochen sollen die ersten Impfstoffe gegen das neuartige Coronavirus
getestet werden Eine Erfolgsgarantie gebe es allerdings nicht.
Laut Experten dürfte es aber mindestens ein Jahr dauern, bis ein fertiger Impfstoff
zur Verfügung steht.

-----------------------------------------
I speculate they could somehow reduce the testing phase, if time urges,
That makes it somehow risky, but hey, the pandemic is the bigger risk.
I can't find any statements on this, though. But maybe they mustn't talk
about this ... it's all commercial,legal.government - they can't just speak freely.

Jan.29
China coronavirus: Hong Kong researchers have already developed vaccine but need
time to test it, expert reveals

Johnson & Johnson JNJ, +0.70%  now plans to initiate development of a vaccine
candidate for 2019-nCoV and is also providing its antiviral HIV treatment Prezcobix in
China for investigational purposes.
Becton Dickinson and Co. BDX, -0.02%, the diagnostics company, is sending
instruments used in diagnostic testing to China

TAWA — Canada’s chief public health officer says it will likely take at least a year
before a vaccine is developed to protect people against the new coronavirus t
 Dr. Theresa Tam

Jan.29 , Novartis CEO
it will take over a year until there is a vaccine

[in Europe or worldwide ? also in China with maybe reduced trial-regulations ? ]

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Vaxart, Inc., a clinical-stage biotechnology company developing oral recombinant vaccines
 administered by tablet rather than by injection, announced on Jan.31 that it has initiated
a program to develop a coronavirus vaccine candidate based on its proprietary oral
vaccine platform, VAAST.
----------------------------------------------------------------------------
Feb-05   Sweden: Karolinska joins global hunt for coronavirus vaccine.
--------------------------------------------------------------------
Der britische Epidemiologe Jeremy Farrar geht davon aus, dass ein Impfstoff gegen das neuartige Coronavirus 2019-nCoV zu spät kommen wird, um die drohende globale Ausbreitung der Seuche zu verhindern. „Realistischerweise wird ein Impfstoff frühestens zum Jahresende fertig oder in einem Jahr – und das wäre schon in Rekordzeit“, sagte Farrar dem „Spiegel“. Wenn man Pech habe, werde es „niemals gelingen“.

Der Direktor des Wellcome Trust

„Es könnte sogar sein, dass das neuartige Coronavirus anders als Influenzaviren nicht nur hauptsächlich saisonal auftritt, sondern das ganze Jahr kursiert“, so der Mediziner weiter. Er bezweifelt, dass die Bewohner westlicher Metropolen wie München oder Paris im Falle einer Pandemie eine wochenlange Abriegelung ihrer Städte wie in China hinnehmen würden.

Wenn alles nach Plan läuft, könnte es bis zum Jahresende ein Serum geben. Ist ein Impfstoff gefunden, muss er noch einen langen Weg bis zur Zulassung gehen.

-------------------------------------------------------------

gsgs:
----------------------------------------------------------------------
Researchers in China and the US are developing a vaccine for the new Coronavirus.
If all goes well, they may run the first tests in three months. A vaccine would be
available mid-year — at the very earliest.
https://www.dw.com/en/coronavirus-vaccine-a-race-against-time/a-52174737
------------------------------------------------------------------
Even if it all goes well, the earliest a vaccine against nCoV could be introduced would
be the summer of 2020.
-----------------------------------------------------------------
Another potential approach against the coronavirus nCoV is with monoclonal antibodies,
which can activate specific immunological reactions in the body.
Herbert Virgin at Vir Biotechnology in Illinois, USA, says his company has developed
antibodies which have shown themselves to be effective against SARS and MERS in
laboratory tests. Some were reportedly able to neutralize coronaviruses. "It's possible that
they could also treat the Wuhan virus," says Virgin.
-----------------------------------------------------------------
Prof. Mark Harris, a virologist at the School for Molecular and Cell Biology at the
University of Leeds in the UK, estimates the mortality rate of nCoV to be at 0.1 percent.
---------------------------------------------------------
A spokesman for the Institutes (NIH) said that it could be a few months before the first
 clinical trials of the vaccine get underway – and a year or more before it’s available.
----------------------------------------
Meanwhile, Baylor College of Medicine in Houston is also reported to be working on a vaccine.
----------------------------------------
so they are going to test it on animals who so far have not been found to catch the virus
 so whats that going to prove apart from if it does not kill an animal it MAY be ok for
 humans why not just test it on a confirmed subject and bypass animal crue..
--------------------------------------
Feb.12
The first vaccine targeting the new coronavirus could be 18 months away, and the outbreak
could end up creating a global threat potentially worse than terrorism, the WHO has warned.
--------------------------------------------------
At least a dozen research teams globally have already made headway in vaccine research
against the new coronavirus.
-----------------------------------------------------
Dr. Anthony Fauci, director of the NIAID, said they are on track to test their vaccine by April.
“Whenever you’re dealing with a vaccine, there’s always a potential for glitches,”
 “Right now, all those glitches, they’ve been overcome.”
Phase one of human testing will still take at least three months to complete, he said.
Then a decision has to be made about whether the vaccine will advance to a phase two trial.
“The risk is the companies now have to invest a lot of money,” Fauci said. “You would
have to do a trial of several hundred to several thousand people to see if it works —
that usually takes anywhere from several months to a couple of years.”
Even with expedited approval, phase two of the new coronavirus vaccine would require
a time investment of at least a year, he said.
------------------------------------------------
The 'holy grail' universal vaccine
Another competitive advantage the team enjoys is Hogue’s prior experience working
on a SARS vaccine, which should speed up their work on the new coronavirus vaccine,
since the new virus is about 80% similar to SARS at the genetic level.
In hindsight, Hogue wishes she had continued to work on her SARS vaccine.
"At the time we were pursuing this, we didn't have all that background and understanding
that there were a lot of these SARS-like viruses that could infect humans,” she said.
-------------------------------------------------------
An expert in infectious diseases on Monday said it was possible there could be a vaccine
against the new virus originating in China "at the very earliest" by September.
Chair of Infectious Disease Epidemiology at Imperial College London, Professor Azra Ghani,
added "it's more likely to be towards the end of the year".
----------------------------------------------------------
In Kooperation mit dem Forscherteam um Sutter arbeitet auch eine Gruppe
um den Virologen Stephan Becker, Direktor des Instituts für Virologie an der
Philipps Universität Marburg und Koordinator des Forschungsbereichs
Neu auftretende Infektionskrankheiten am Deutschen Zentrum für
Infektionsforschung (DZIF), an einem Impfstoffkandidaten.
Wenn der politische oder medizinische Druck hoch genug sei, dann würden
die Zulassungsverfahren beschleunigt, zeigten seine Erfahrungen.
-------------------------------------------------------


gsgs:
@HelenBranswell
This feels very optimistic for vaccine for the masses.
Some people *may* get vaccinated in 18 months. But it won't be most of us.
----------------------------------------------------
@florian_krammer
Vaccines against SARS-CoV-2 will be very important. But don't get fooled by press releases.
To get them will take time.
 Merck and J&J did their phase 1-2-3 more or less in parallel. Will the FDA / EMA allow such
an approach for covid-19 vaccine?. I would hope so.
@nataliexdean
If Phase 3 trials are successful, there is also a precedent for immediately providing the vaccine
under an emergency use authorization (pre-licensure) as long as recipients provide informed
consent. This has been done in the DRC for Ebola.
Woman shrugging
@fodaazul
6 to 18 months? There’s 4 to 16 months left only


gsgs:
https://www.republicworld.com/world-news/rest-of-the-world-news/expert-virus-vaccine-possible-by-sep-at-earliest.html

Azra Chani
Azra Ghani,

Weiner, Imp.Coll.London
“We were able to go from no vaccine to a vaccine tested in the clinic in about 18 months — 15 to 18 months,”
 “And we were able to design and develop and move into the clinic in 11 months [MERS].”
Keith Chappell at the University of Queensland in Brisbane, Australia, thinks he can do even better
https://cbdnewsupdate.com/timetable-for-a-vaccine-against-the-new-coronavirus-maybe-this-fall/
Even in the rosiest of scenarios, Hatchett says, once the vaccine is in hand, it still needs to get to the people who need it, and that takes time — at least weeks to months, depending on the urgency.
“We are making very aggressive efforts in the hopes of having a vaccine available — some form of vaccine available, potentially, as early as this fall,” Hatchett says.

gsgs:
Fauci repeating on Mar02 : Fauci :
“A year to a year and a half,” referring to the amount of time it will likely take to
deploy an effective vaccine to large populations.

[ with their approach ? with current US-vaccine-laws ? ]
==================================================

More than 20 new crown pneumonia vaccines are being developed worldwide, and these
have made new progress
-----------------------------------------------------------------------------------
American pharmaceutical company Inovio Pharmaceuticals said on March 3 that the company is
 accelerating the development of a vaccine schedule for the treatment of new coronary pneumonia.
 Inovio is currently expected to provide 1 million doses of vaccines using existing resources
by the end of the year.
-------------------------------------------------------------------------------------------------
It is reported that the laboratory team led by Professor Robin Shattock, head of mucosal
infections and immunology at Imperial College London, focuses on the development of a
coronavirus vaccine. They developed the vaccine within 14 days and last week Began
to enter the animal test stage, and it is possible to conduct human trials within 5 months.
 If progress is smooth, human clinical trials will be conducted this summer. (Finished by
Health Times reporter Qiao Jingfang)
----------------------------------------------------------------------------------------------
! Professor Ning Yi from the School of Public Health of Peking University said in an interview
with a Health Times reporter that the fastest time from vaccine development to market is 6 months,
and the probability of successful vaccine development before August is "zero".
--------------------------------------------------------------------------------------------
US pharmaceutical company Moderna has sent vaccine samples to U.S. government researchers
this Monday. It is expected to be tested on 45 healthy volunteers by the end of April. The first
phase will take at least three months. Then entering the second phase will require hundreds of
volunteers to test, and the rocket speed will also take 6-8 months. That is to say, the fastest time
is one to one and a half years.
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